Wright SS#, Kumari P#, Fraile-Ágreda V, Wang C, Shivcharan S, Kappelhoff S, Margheritis EG, Matz A, Vasudevan SO, Rubio I, Bauer M, Zhou B, Vanaja SK, Cosentino K, Ruan J, Rathinam VA. Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells. Cell. 2025 Jan 23;188(2):280-291.e17. doi: 10.1016/j.cell.2024.11.018. Epub 2024 Dec 31. PubMed PMID: 39742811. (#Contributed equally)
Kumari P, Wright SS, Rathinam VA. Role of Extracellular Vesicles in Immunity and Host Defense. Immunol Invest. 2024 Jan;53(1):10-25. doi: 10.1080/08820139.2024.2312896. Epub 2024 Feb 13. Review. PubMed PMID: 38348776; PubMed Central PMCID: PMC11111308.
Kumari P, Vasudevan SO, Russo AJ, Wright SS, Fraile-Ágreda V, Krajewski D, Jellison ER, Rubio I, Bauer M, Shimoyama A, Fukase K, Zhang Y, Pachter JS, Vanaja SK, Rathinam VA. Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis. Nat Cell Biol. 2023 Dec;25(12):1860-1872. doi: 10.1038/s41556-023-01269-8. Epub 2023 Nov 16. PubMed PMID: 37973841; PubMed Central PMCID: PMC11111309.
Ta A, Ricci-Azevedo R, Vasudevan SO, Wright SS, Kumari P, Havira MS, Surendran Nair M, Rathinam VA, Vanaja SK. A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3. Nat Commun. 2023 Apr 11;14(1):2035. doi: 10.1038/s41467-023-37812-2. PubMed PMID: 37041208; PubMed Central PMCID: PMC10090168.
Vasudevan SO, Russo AJ, Kumari P, Vanaja SK, Rathinam VA. A TLR4-independent critical role for CD14 in intracellular LPS sensing. Cell Rep. 2022 May 3;39(5):110755. doi: 10.1016/j.celrep.2022.110755. PubMed PMID: 35508125; PubMed Central PMCID: PMC9376664.
Fan Z, Pitmon E, Wen L, Miller J, Ehinger E, Herro R, Liu W, Chen J, Mikulski Z, Conrad DJ, Marki A, Orecchioni M, Kumari P, Zhu YP, Marcovecchio PM, Hedrick CC, Hodges CA, Rathinam VA, Wang K, Ley K. Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice. J Immunol. 2022 Feb 1;208(3):745-752. doi: 10.4049/jimmunol.1901171. Epub 2022 Jan 14. PubMed PMID: 35031577; PubMed Central PMCID: PMC8855460.
Mishra S, Raj AS, Kumar A, Rajeevan A, Kumari P, Kumar H. Innate immune sensing of influenza A viral RNA through IFI16 promotes pyroptotic cell death. iScience. 2022 Jan 21;25(1):103714. doi: 10.1016/j.isci.2021.103714. eCollection 2022 Jan 21. PubMed PMID: 35072006; PubMed Central PMCID: PMC8762390.
Kumari P, Kumar H. Dimensions of inflammation in host defense and diseases. Int Rev Immunol. 2022;41(1):1-3. doi: 10.1080/08830185.2022.2014174. PubMed PMID: 35044868.
Kumari P, Russo AJ, Wright SS, Muthupalani S, Rathinam VA. Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense. Cell Rep. 2021 Apr 20;35(3):109012. doi: 10.1016/j.celrep.2021.109012. PubMed PMID: 33882312; PubMed Central PMCID: PMC8451177.
Russo AJ, Vasudevan SO, Méndez-Huergo SP, Kumari P, Menoret A, Duduskar S, Wang C, Pérez Sáez JM, Fettis MM, Li C, Liu R, Wanchoo A, Chandiran K, Ruan J, Vanaja SK, Bauer M, Sponholz C, Hudalla GA, Vella AT, Zhou B, Deshmukh SD, Rabinovich GA, Rathinam VA. Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Nat Immunol. 2021 Feb;22(2):154-165. doi: 10.1038/s41590-020-00844-7. Epub 2021 Jan 4. PubMed PMID: 33398185; PubMed Central PMCID: PMC8916041.
Havira MS, Ta A, Kumari P, Wang C, Russo AJ, Ruan J, Rathinam VA, Vanaja SK. Shiga toxin suppresses noncanonical inflammasome responses to cytosolic LPS. Sci Immunol. 2020 Nov 27;5(53). doi: 10.1126/sciimmunol.abc0217. PubMed PMID: 33246946; PubMed Central PMCID: PMC7717664.
Kumari P, Russo AJ, Shivcharan S, Rathinam VA. AIM2 in health and disease: Inflammasome and beyond. Immunol Rev. 2020 Sep;297(1):83-95. doi: 10.1111/imr.12903. Epub 2020 Jul 26. Review. PubMed PMID: 32713036; PubMed Central PMCID: PMC7668394.
Kumari P, Kumar H. Viral deubiquitinases: role in evasion of anti-viral innate immunity. Crit Rev Microbiol. 2018 May;44(3):304-317. doi: 10.1080/1040841X.2017.1368999. Epub 2017 Sep 8. Review. PubMed PMID: 28885059.
Kumari P, Saha I, Narayanan A, Narayanan S, Takaoka A, Kumar NS, Tailor P, Kumar H. Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways. Cell Death Dis. 2017 Oct 5;8(10):e3078. doi: 10.1038/cddis.2017.461. PubMed PMID: 28981114; PubMed Central PMCID: PMC5680583.
Kumari P, Narayanan S, Kumar H. Herpesviruses: interfering innate immunity by targeting viral sensing and interferon pathways. Rev Med Virol. 2015 May;25(3):187-201. doi: 10.1002/rmv.1836. Epub 2015 Apr 1. Review. PubMed PMID: 25847408.
Kumari P and Gupta A. Assays to assess the proliferative behavior of cancer cells. Protocol handbook for cancer biology, Book Chapter 3, Pages 23-41, 2021